An Enantiomeric Fragment Pair (EFP) Approach for the Study of Cellular Uptake of Intrinsically Disordered Proteins
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200146
Abstract: The study of intrinsically disordered and amyloidogenic proteins poses a major challenge to researchers due to the propensity of the system to aggregate and to form amyloid fibrils and deposits. This intrinsic nature limits the… read more here.
Keywords: intrinsically disordered; disordered proteins; enantiomeric fragment; approach study ... See more keywords
Efficacy of independence sampling in replica exchange simulations of ordered and disordered proteins
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.24923
Abstract: Recasting temperature replica exchange (T‐RE) as a special case of Gibbs sampling has led to a simple and efficient scheme for enhanced mixing (Chodera and Shirts, J. Chem. Phys., 2011, 135, 194110). To critically examine… read more here.
Keywords: independence sampling; replica exchange; simulations ordered; ordered disordered ... See more keywords
Interactions between the Intrinsically Disordered Proteins β‐Synuclein and α‐Synuclein
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DOI: 10.1002/pmic.201800109
Abstract: Several intrinsically disordered proteins have been implicated in the process of amyloid fibril formation in neurodegenerative disease, and developing approaches to inhibit the aggregation of these intrinsically disordered proteins is critical for establishing effective therapies… read more here.
Keywords: beta synuclein; synuclein; alpha synuclein; disordered proteins ... See more keywords
Prediction of nearest neighbor effects on backbone torsion angles and NMR scalar coupling constants in disordered proteins
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3292
Abstract: Using fine‐tuned hydrogen bonding criteria, a library of coiled peptide fragments has been generated from a large set of high‐resolution protein X‐ray structures. This library is shown to be an improved representation of ϕ/ψ torsion… read more here.
Keywords: nearest neighbor; coupling constants; disordered proteins; torsion angles ... See more keywords
Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_60
Abstract: The formation of protein aggregates and inclusions in the brain and spinal cord is a common neuropathological feature of a number of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS),… read more here.
Keywords: protein; small molecule; neurodegenerative diseases; protein aggregation ... See more keywords
Structural Analyses of Intrinsically Disordered Proteins by Small-Angle X-Ray Scattering.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0524-0_12
Abstract: Small-angle X-ray scattering (SAXS) is a low-resolution method for the structural characterization of biological macromolecules in solution. Information about the overall structural features provided by SAXS is highly complementary to X-ray crystallography, nuclear magnetic resonance… read more here.
Keywords: small angle; structural analyses; angle ray; ray scattering ... See more keywords
Protocol for Investigating the Interactions Between Intrinsically Disordered Proteins and Membranes by Neutron Reflectometry.
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DOI: 10.1007/978-1-0716-0524-0_29
Abstract: Several intrinsically disordered proteins (IDPs) exhibit high affinity for lipid membranes. Among the different biophysical methods to probe protein-lipid interaction, neutron reflectometry (NR) can provide direct and structural detailed information on the location of the… read more here.
Keywords: neutron reflectometry; protocol; interaction; membrane ... See more keywords
Intrinsically Disordered Proteins (IDP): Purification Under Denaturing Conditions.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1859-2_21
Abstract: Recombinant protein expression in E. coli often induces the expressed protein to accumulate in insoluble aggregates, named inclusion bodies (IBs), that represent easy to isolate, highly pure protein reservoirs. IBs can be solubilized by denaturing… read more here.
Keywords: proteins idp; purification denaturing; disordered proteins; intrinsically disordered ... See more keywords
Behaviour of intrinsically disordered proteins in protein–protein complexes with an emphasis on fuzziness
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DOI: 10.1007/s00018-017-2560-7
Abstract: Intrinsically disordered proteins (IDPs) do not, by themselves, fold into a compact globular structure. They are extremely dynamic and flexible, and are typically involved in signalling and transduction of information through binding to other macromolecules.… read more here.
Keywords: proteins protein; protein protein; binding; behaviour intrinsically ... See more keywords
Targeting intrinsically disordered proteins involved in cancer
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DOI: 10.1007/s00018-019-03347-3
Abstract: Intrinsically disordered proteins (IDPs) do not have a well-defined structure under physiological conditions, but they have key roles in cell signaling and regulation, and they are frequently related to the development of diseases, such as… read more here.
Keywords: involved cancer; targeting intrinsically; cancer; targeting idps ... See more keywords
Proteus: a random forest classifier to predict disorder-to-order transitioning binding regions in intrinsically disordered proteins
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0020-y
Abstract: The focus of the computational structural biology community has taken a dramatic shift over the past one-and-a-half decades from the classical protein structure prediction problem to the possible understanding of intrinsically disordered proteins (IDP) or… read more here.
Keywords: disorder order; order transitioning; disorder; disordered proteins ... See more keywords