An enhancer sequence in the intrinsically disordered region of FtsZ promotes polymer‐guided substrate processing by ClpXP protease
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DOI: 10.1002/pro.4306
Abstract: The essential bacterial division protein in Escherichia coli, FtsZ, assembles into the FtsZ‐ring at midcell and recruits other proteins to the division site to promote septation. A region of the FtsZ amino acid sequence that… read more here.
Keywords: intrinsically disordered; region ftsz; region; polymer guided ... See more keywords
The BEG Model in the Disordered Region and at the Antiquadrupolar-Disordered Line of Parameters
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DOI: 10.1007/s10955-019-02431-z
Abstract: We analyse the d -dimensional BEG model with $$d\ge 2$$ d ≥ 2 and parameters in the disordered region and at the antiquadrupolar-disordered line. We obtain a subset of these regions for which the odd… read more here.
Keywords: region antiquadrupolar; antiquadrupolar disordered; disordered line; beg model ... See more keywords
Phosphorylation tunes elongation propensity and cohesiveness of INCENP's intrinsically disordered region.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167387
Abstract: The inner centromere protein, INCENP, is crucial for correct chromosome segregation during mitosis. It connects the kinase Aurora B to the inner centromere allowing this kinase to dynamically access its kinetochore targets. However, the function… read more here.
Keywords: phosphorylation; propensity; disordered region; intrinsically disordered ... See more keywords
Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2
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DOI: 10.1126/sciadv.aav9810
Abstract: The intrinsically disordered region of MBD2 is a promising target for treating cancer metastasis. Although intrinsically disordered protein regions (IDPRs) are commonly engaged in promiscuous protein-protein interactions (PPIs), using them as drug targets is challenging… read more here.
Keywords: rational discovery; mbd2; region mbd2; intrinsically disordered ... See more keywords
NKCC1 and KCC2: Structural insights into phospho-regulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.964488
Abstract: Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30–50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl–… read more here.
Keywords: nkcc1 kcc2; region; kcc2 structural; regulation ... See more keywords
Regulatory Roles of the N-Terminal Intrinsically Disordered Region of Modular Src
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DOI: 10.3390/ijms23042241
Abstract: Src, the prototype of Src family kinases (SFKs), is a modular protein consisting of SH4 (SH4) and unique (UD) domains in an N-terminal intrinsically disordered region (IDR), and SH3, SH2, and kinase (KD) folded domains… read more here.
Keywords: intrinsically disordered; regulatory roles; disordered region; terminal intrinsically ... See more keywords
The Emergence of New Catalytic Abilities in an Endoxylanase from Family GH10 by Removing an Intrinsically Disordered Region
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DOI: 10.3390/ijms23042315
Abstract: Endoxylanases belonging to family 10 of the glycoside hydrolases (GH10) are versatile in the use of different substrates. Thus, an understanding of the molecular mechanisms underlying substrate specificities could be very useful in the engineering… read more here.
Keywords: gh10; intrinsically disordered; family; disordered region ... See more keywords
Functional Characterization of the N-Terminal Disordered Region of the piggyBac Transposase
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DOI: 10.3390/ijms231810317
Abstract: The piggyBac DNA transposon is an active element initially isolated from the cabbage looper moth, but members of this superfamily are also present in most eukaryotic evolutionary lineages. The functionally important regions of the transposase… read more here.
Keywords: piggybac; transposase; terminal disordered; disordered region ... See more keywords