The return of the rings: Evolutionary convergence of aromatic residues in the intrinsically disordered regions of RNA‐binding proteins for liquid–liquid phase separation
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4317
Abstract: Aromatic residues appeared relatively late in the evolution of protein sequences to stabilize the globular proteins' folding core and are less in the intrinsically disordered regions (IDRs). Recent advances in protein liquid–liquid phase separation (LLPS)… read more here.
Keywords: intrinsically disordered; liquid phase; aromatic residues; disordered regions ... See more keywords
Disorder for Dummies: Functional Mutagenesis of Transient Helical Segments in Disordered Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0524-0_1
Abstract: Most cytosolic eukaryotic proteins contain a mixture of ordered and disordered regions. Disordered regions facilitate cell signaling by concentrating sites for posttranslational modifications and protein-protein interactions into arrays of short linear motifs that can be… read more here.
Keywords: disordered regions; transient helical; dummies functional; helical segments ... See more keywords
Screening Intrinsically Disordered Regions for Short Linear Binding Motifs.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0524-0_27
Abstract: The intrinsically disordered regions of the proteome are enriched in short linear motifs (SLiMs) that serve as binding sites for peptide binding proteins. These interactions are often of low-to-mid micromolar affinities and are challenging to… read more here.
Keywords: screening intrinsically; disordered regions; regions short; short linear ... See more keywords
Dynamic Studies on Intrinsically Disordered Regions of Two Paralogous Transcription Factors Reveal Rigid Segments with Important Biological Functions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.02.021
Abstract: Long stretches of intrinsically disordered regions (IDRs) are abundantly present in eukaryotic transcription factors. Although their biological significance is well appreciated, the underlying structural and dynamic mechanisms of their function are still not clear. Using… read more here.
Keywords: rigid segments; transcription; disordered regions; two paralogous ... See more keywords
Prediction of disordered regions in proteins with recurrent Neural Networks and protein dynamics.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167579
Abstract: The role of intrinsically disordered protein regions (IDRs) in cellular processes has become increas- ingly evident over the last years. These IDRs continue to challenge structural biology experiments be- cause they lack a well-defined conformation,… read more here.
Keywords: biology; prediction disordered; protein dynamics; disordered regions ... See more keywords
Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23268-9
Abstract: Recent cryo-EM structures show the highly dynamic nature of the MLL1-NCP (nucleosome core particle) interaction. Functional implication and regulation of such dynamics remain unclear. Here we show that DPY30 and the intrinsically disordered regions (IDRs)… read more here.
Keywords: disordered regions; dpy30; mll set1; dpy30 ash2l ... See more keywords
Investigating how intrinsically disordered regions contribute to protein function using HDX-MS.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220206
Abstract: A large amount of the human proteome is composed of highly dynamic regions that do not adopt a single static conformation. These regions are defined as intrinsically disordered, and they are found in a third… read more here.
Keywords: hdx; intrinsically disordered; disordered regions; regions contribute ... See more keywords
The potential of intrinsically disordered regions in vaccine development
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2022.1997600
Abstract: A comprehensive insight into how each part of a protein work can result in a better understanding of its role in cells and biological activities. According to the classical structurefunction paradigm, proteins following the translation… read more here.
Keywords: response; disordered regions; intrinsically disordered; protein ... See more keywords
DeepIDP-2L: protein intrinsically disordered region prediction by combining convolutional attention network and hierarchical attention network
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab810
Abstract: MOTIVATION Intrinsically disordered regions (IDRs) are widely distributed in proteins. Accurate prediction of IDRs is critical for the protein structure and function analysis. The IDRs are divided into long disordered regions (LDRs) and short disordered… read more here.
Keywords: attention network; disordered regions; ldrs sdrs; attention ... See more keywords
SLiMSearch: a framework for proteome-wide discovery and annotation of functional modules in intrinsically disordered regions
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx238
Abstract: Abstract The extensive intrinsically disordered regions of higher eukaryotic proteomes contain vast numbers of functional interaction modules known as short linear motifs (SLiMs). Here, we present SLiMSearch, a motif discovery tool that scans a motif… read more here.
Keywords: motif; disordered regions; annotation; discovery ... See more keywords
Targeting intrinsically disordered regions facilitates discovery of calcium channels 3.2 inhibitory peptides for adeno-associated virus–mediated peripheral analgesia
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002650
Abstract: Supplemental Digital Content is Available in the Text. Targeting intrinsically disordered regions facilitates discovery of T-type/calcium channels 3.2 (CaV3.2) inhibitory peptides. Adeno-associated virus–mediated expression of prototypic CaV3.2iPA1 and 2 in dorsal root ganglia primary sensory… read more here.
Keywords: calcium; intrinsically disordered; facilitates discovery; regions facilitates ... See more keywords