Disordered Substrates of the 20S Proteasome Link Degradation with Phase Separation
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DOI: 10.1002/pmic.201800276
Abstract: The 20S proteasome is known to degrade intrinsically disordered proteins (IDPs) via an ubiquitin‐independent, disorder‐driven mechanism. Unless protected within protein complexes or macromolecular assemblies, certain IDPs can undergo degradation mediated directly by the 20S core… read more here.
Keywords: degradation; phase; substrates 20s; 20s proteasome ... See more keywords
Elastic Interfaces on Disordered Substrates: From Mean-Field Depinning to Yielding.
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DOI: 10.1103/physrevlett.123.218002
Abstract: We consider a model of an elastic manifold driven on a disordered energy landscape, with generalized long range elasticity. Varying the form of the elastic kernel by progressively allowing for the existence of zero modes,… read more here.
Keywords: field depinning; elastic interfaces; field; disordered substrates ... See more keywords