Small Angle Neutron Scattering Studies of R67 Dihydrofolate Reductase, a Tetrameric Protein with Intrinsically Disordered N-Termini
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DOI: 10.1021/acs.biochem.7b00822
Abstract: R67 dihydrofolate reductase (DHFR) is a homotetramer with a single active site pore and no sequence or structural homology with chromosomal DHFRs. The R67 enzyme provides resistance to trimethoprim, an active site-directed inhibitor of Escherichia… read more here.
Keywords: protein; dhfr; dihydrofolate reductase; r67 dihydrofolate ... See more keywords
Robustness by intrinsically disordered C-termini and translational readthrough
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DOI: 10.1093/nar/gky778
Abstract: Abstract During protein synthesis genetic instructions are passed from DNA via mRNA to the ribosome to assemble a protein chain. Occasionally, stop codons in the mRNA are bypassed and translation continues into the untranslated region… read more here.
Keywords: translational readthrough; robustness intrinsically; disordered termini; termini translational ... See more keywords