Advances in the discovery and development of selective heme-displacing IDO1 inhibitors
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DOI: 10.1080/17460441.2020.1781811
Abstract: ABSTRACT Introduction Indoleamine 2,3-dioxygenase 1 (IDO1) has been considered as an attractive intracellular target for the development of small-molecule cancer immunotherapy. Results in human clinical studies indicated that the first-generation IDO1 inhibitor epacadostat lacked anticancer… read more here.
Keywords: heme; heme displacing; displacing ido1; ido1 inhibitors ... See more keywords