Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
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DOI: 10.1016/j.celrep.2018.09.076
Abstract: Huntington's disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the Huntingtin (HTT) gene. Induced pluripotent stem cell (iPSC) models of HD provide an opportunity to study the mechanisms underlying disease… read more here.
Keywords: huntington disease; disease; altered transcriptomics; display altered ... See more keywords
Adipose tissues of MPC1± mice display altered lipid metabolism-related enzyme expression levels
Sign Up to like & getrecommendations! Published in 2018 at "PeerJ"
DOI: 10.7717/peerj.5799
Abstract: Mitochondrial pyruvate carrier 1 (MPC1) is a component of the MPC1/MPC2 heterodimer that facilitates the transport of pyruvate into mitochondria. Pyruvate plays a central role in carbohydrate, fatty, and amino acid catabolism. The present study… read more here.
Keywords: mpc1 mice; metabolism; tissues mpc1; mice display ... See more keywords