Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
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DOI: 10.1126/sciadv.abq0651
Abstract: The most common genetic mutation found in familial and sporadic amyotrophic lateral sclerosis (ALS), as well as fronto-temporal dementia (FTD), is a repeat expansion in the C9orf72 gene. C9orf72 is highly expressed in human myeloid… read more here.
Keywords: derived microglia; disrupted autophagy; cell autonomous; c9orf72 als ... See more keywords