Disrupted‐in‐schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization
Sign Up to like & getrecommendations! Published in 2019 at "Hippocampus"
DOI: 10.1002/hipo.23076
Abstract: Aberrant proteostasis of protein aggregation may lead to behavior disorders including chronic mental illnesses (CMI). Furthermore, the neuronal activity alterations that underlie CMI are not well understood. We recorded the local field potential and single‐unit… read more here.
Keywords: hippocampal coding; overexpression disrupts; disrupts hippocampal; schizophrenia overexpression ... See more keywords
Association study of Disrupted-In-Schizophrenia-1 gene variants and tardive dyskinesia
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.08.007
Abstract: Tardive dyskinesia (TD) is an involuntary movement disorder that occurs in ∼20% of patients after extended antipsychotic use. Its pathophysiology is unclear; however, familial patterns and gene association studies indicate an inherited component to risk.… read more here.
Keywords: gene variants; tardive dyskinesia; association; gene ... See more keywords
Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.10.055
Abstract: D-Serine, an endogenous coagonist of N-methyl-d-aspartate receptors (NMDARs) at the glycine binding site, is synthesized by serine racemase (SR) through conversion of l-Serine. Dysregulation of SR/D-Serine and Disrupted-In-Schizophrenia-1 (DISC1) contributes to the pathogenesis of schizophrenia… read more here.
Keywords: serine racemase; serine; disc1 agglomerates; schizophrenia disc1 ... See more keywords
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1
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DOI: 10.1038/s41398-021-01212-1
Abstract: Disrupted-in-schizophrenia 1 (DISC1) is a scaffold protein that has been implicated in multiple mental disorders. DISC1 is known to regulate neuronal proliferation, signaling, and intracellular calcium homeostasis, as well as neurodevelopment. Although DISC1 was linked… read more here.
Keywords: bmal1; disc1; disrupted schizophrenia; circadian rhythm ... See more keywords
Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191162
Abstract: Accumulating evidence suggests an important role for the Disrupted-in-Schizophrenia 1 (DISC1) protein in neurodevelopment and chronic mental illness. In particular, the C-terminal 300 amino acids of DISC1 have been found to mediate important protein-protein interactions… read more here.
Keywords: protein; chain; antibody; disrupted schizophrenia ... See more keywords