Thermo-sensitive polypeptide hydrogel for locally sequential delivery of two-pronged antitumor drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.05.053
Abstract: In the synergistic treatment with cytotoxic drug and vascular disrupting agent, the order of drug release shows great importance to enhance the antitumor efficacy. When vascular disrupting agent is firstly administrated, the reduced blood supply… read more here.
Keywords: disrupting agent; hydrogel; delivery; vascular disrupting ... See more keywords
A vascular disrupting agent overcomes tumor multidrug resistance by skewing macrophage polarity toward the M1 phenotype.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.01.016
Abstract: Multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters is the major obstacle for chemotherapeutic success. Although attempts have been made to circumvent ABC transporter-mediated MDR in past decades, there is still no effective agent… read more here.
Keywords: agent; disrupting agent; vascular disrupting; multidrug resistance ... See more keywords