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Disrupting G6PD-mediated Redox homeostasis enhances chemosensitivity in colorectal cancer

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0 Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2017.227

Abstract: Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that generates NADPH to maintain reduced glutathione (GSH), which scavenges reactive oxygen species (ROS) to protect cancer cell from oxidative damage. In this study, we mainly investigate the… read more here.

Keywords: g6pd; g6pd mediated; homeostasis enhances; colorectal cancer ... See more keywords