Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13301
Abstract: In humans, germline TP53 mutations predispose carriers to a wide spectrum of cancers, which is known as Li–Fraumeni syndrome (LFS). To date, the association of melanomas with LFS remains unestablished. No melanomas have been reported… read more here.
Keywords: disruption; xenopus tropicalis; tp53; lfs ... See more keywords
Biomimetic Electronic Devices for Measuring Bacterial Membrane Disruption.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201808234
Abstract: Antibiotic discovery has experienced a severe slowdown in terms of discovery of new candidates. In vitro screening methods using phospholipids to model the bacterial membrane provide a route to identify molecules that specifically disrupt bacterial… read more here.
Keywords: membrane disruption; disruption; biomimetic electronic; electronic devices ... See more keywords
Synergistic Disruption of Metabolic Homeostasis through Hyperbranched Poly(ethylene glycol) Conjugates as Nanotherapeutics to Constrain Cancer Growth
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109036
Abstract: Combination therapy is a promising approach for effective treatment of tumors through synergistically regulating pathways. However, the synergistic effect is limited, likely by uncontrolled co‐delivery of different therapeutic payloads in a single nanoparticle. Herein, a… read more here.
Keywords: disruption; poly ethylene; hyperbranched poly; ethylene glycol ... See more keywords
Disruption of the Blood-Brain Barrier Predicts Progression of Cerebral Small Vessel Disease White Matter Hyperintensities.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of neurology"
DOI: 10.1002/ana.78072
Abstract: OBJECTIVE The objective of this study was to test if blood-brain barrier (BBB) disruption, detected using dynamic susceptibility contrast (DSC) imaging, would predict progression of white matter hyperintensities (WMHs) over the subsequent year in patients… read more here.
Keywords: white matter; brain; bbb disruption; progression ... See more keywords
Evaluation on H2O2-aided ultrasonic pretreatment for cell disruption of Chlorella pyrenoidosa
Sign Up to like & getrecommendations! Published in 2017 at "Asia-Pacific Journal of Chemical Engineering"
DOI: 10.1002/apj.2093
Abstract: In this work, Chlorella pyrenoidosa was chosen as model microalgae, and several pretreatments, including hydroxyl-peroxide-aided ultrasonic pretreatments and mono-ultrasonication (US), were used to rupture the microalgal cells for extracting cellular inclusion. The disruption efficiency and… read more here.
Keywords: disruption; aided ultrasonic; cell disruption; cell ... See more keywords
Quantifying scientific breakthroughs by a novel disruption indicator based on knowledge entities
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Association for Information Science and Technology"
DOI: 10.1002/asi.24719
Abstract: Compared to previous studies that generally detect scientific breakthroughs based on citation patterns, this article proposes a knowledge entity‐based disruption indicator by quantifying the change of knowledge directly created and inspired by scientific breakthroughs to… read more here.
Keywords: disruption indicator; indicator based; disruption; knowledge ... See more keywords
Hypothesis: By‐products of vascular disruption carried in the CSF affect prenatal brain development
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2064
Abstract: Prenatal CNS disruptions can be associated with physically separate findings. Examples include cognitive issues in septo‐optic dysplasia and sporadic and WNT1‐related unilateral cerebellar hypoplasia, and physical findings such as thinning of the corpus callosum, ventriculomegaly,… read more here.
Keywords: development; brain; disruption; hypothesis products ... See more keywords
Microscale disruption of microorganisms for parallelized process development
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Journal"
DOI: 10.1002/biot.201600579
Abstract: Escherichia coli, Saccharomyces cerevisiae, and Pichia pastoris are the standard platforms for biopharmaceutical production with 40% of all between 2010 to 2014 approved protein drugs produced in those microbial hosts. Typically, products overexpressed E. coli… read more here.
Keywords: process development; cell disruption; disruption; microscale ... See more keywords
Shining light on carbon dots: Toward enhanced antibacterial activity for biofilm disruption
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400156
Abstract: In spite of tremendous efforts dedicated to addressing bacterial infections and biofilm formation, the post‐antibiotic ear continues to witness a gap between the established materials and an easily accessible yet biocompatible antibacterial reagent. Here we… read more here.
Keywords: carbon dots; antibacterial activity; disruption; biofilm ... See more keywords
A new type of gene‐disruption cassette with a rescue gene for Pichia pastoris
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2541
Abstract: Pichia pastoris has been used for the production of many recombinant proteins, and many useful mutant strains have been created. However, the efficiency of mutant isolation by gene‐targeting is usually low and the procedure is… read more here.
Keywords: rescue gene; system; gene disruption; disruption ... See more keywords
Anger, sad, and blended expressions to contingency disruption in young infants
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Psychobiology"
DOI: 10.1002/dev.21768
Abstract: Three studies elicited young infants' (aged 17-23 weeks) anger and sad facial expressions during brief contingency disruptions to explore their potential organization over time as a biphasic process. Study 1 examined partial correlations among anger, sad,… read more here.
Keywords: anger sad; disruption; sad blended; contingency ... See more keywords