Disruption of conserved polar interactions causes a sequential release of Bim mutants from the canonical binding groove of Mcl1.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.04.243
Abstract: Mcl1 is an important anti-apoptotic member of the Bcl2 family proteins that are upregulated in several cancer malignancies. The canonical binding groove (CBG) located at the surface of Mcl1 exhibits a critical role in binding… read more here.
Keywords: causes sequential; disruption conserved; mcl1; conserved polar ... See more keywords