Disruption of mitochondrial complex I induces progressive parkinsonism.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04059-0
Abstract: Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson's disease1. Yet, whether this change contributes to Parkinson's disease pathogenesis is unclear2. Here we used… read more here.
Keywords: complex induces; disruption mitochondrial; parkinsonism; mitochondrial complex ... See more keywords
Atherosclerosis: from the disruption of mitochondrial membrane potential to the potential interventional strategies.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666221201120405
Abstract: Atherosclerosis (AS) is the major factor of cardiovascular disease (CVD) and is characterized by a progressive and chronic inflammatory process in the arterial wall. Recent studies have shown that disruption of the mitochondrial membrane potential… read more here.
Keywords: disruption mitochondrial; membrane potential; mitochondrial membrane; oxidative stress ... See more keywords
How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12040831
Abstract: In the past, mitochondrial reactive oxygen species (mtROS) were considered a byproduct of cellular metabolism. Due to the capacity of mtROS to cause oxidative damage, they were proposed as the main drivers of ageing and… read more here.
Keywords: mitochondrial redox; disruption mitochondrial; contributes ageing; redox signalling ... See more keywords