Disruption of nucleosomes by DNA groove binders of clinical significance and implications for chromatin remodeling.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216611120
Abstract: Small molecules that bind in the minor groove of DNA are in clinical use as antibiotics and antitumor drugs. Two members of this class of molecules, netropsin and chromomycin, are shown here to displace DNA… read more here.
Keywords: dna; disruption nucleosomes; nucleosomes dna; groove binders ... See more keywords