Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications
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DOI: 10.3390/ph16040616
Abstract: Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein. Proteomic… read more here.
Keywords: disruption proteostasis; natural products; proteostasis natural; multiple myeloma ... See more keywords