Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex
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DOI: 10.1371/journal.pone.0266143
Abstract: Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically… read more here.
Keywords: taz; aurintricarboxylic acid; taz tead; transcriptional complex ... See more keywords