Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-91107-4
Abstract: The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein… read more here.
Keywords: ipomoeassin disrupts; protein biogenesis; multiple aspects; aspects secretory ... See more keywords
Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-020-01720-y
Abstract: Background Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also,… read more here.
Keywords: protein; multiple steps; steps autophagy; disrupts multiple ... See more keywords
Neonatal subarachnoid hemorrhage disrupts multiple aspects of cerebellar development
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1161086
Abstract: Over the past decade, survival rates for extremely low gestational age neonates (ELGANs; read more here.
Keywords: hemorrhage disrupts; hemorrhage; subarachnoid hemorrhage; multiple aspects ... See more keywords