Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02758-9
Abstract: Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly in a complicated milieu such as bone marrow where progenitor stem cells reside. Here,… read more here.
Keywords: treatment disseminated; radionuclides transform; treatment; cancer cells ... See more keywords
Targeted transcript quantification in single disseminated cancer cells after whole transcriptome amplification
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DOI: 10.1371/journal.pone.0216442
Abstract: Gene expression analysis of rare or heterogeneous cell populations such as disseminated cancer cells (DCCs) requires a sensitive method allowing reliable analysis of single cells. Therefore, we developed and explored the feasibility of a quantitative… read more here.
Keywords: cancer cells; cancer; quantification; cell ... See more keywords
Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16040595
Abstract: To enhance targeting efficacy in the radioimmunotherapy of disseminated cancer, several pretargeting strategies have been developed. In pretargeted radioimmunotherapy, the tumor is pretargeted with a modified monoclonal antibody that has an affinity for both tumor… read more here.
Keywords: astatine; chemistry; disseminated cancer; alpha therapy ... See more keywords