Best Practices for Integration of Dissolution Data into Physiologically Based Biopharmaceutics Models (PBBM): A Biopharmaceutics Modeling Scientist Perspective
Sign Up to like & getrecommendations! Published in 2023 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-023-02521-y
Abstract: Dissolution is considered as a critical input into physiologically based biopharmaceutics models (PBBM) as it governs in vivo exposure. Despite many workshops, initiatives by academia, industry, and regulatory, wider practices are followed for dissolution data input… read more here.
Keywords: dissolution; dissolution data; models pbbm; physiologically based ... See more keywords
Physiologically Based Pharmacokinetic (PBPK) Modelling for In Vitro-In Vivo Extrapolation: Emphasis on the Use of Dissolution Data
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DOI: 10.14227/dt260319p18
Abstract: Recently the pharmaceutical sector has witnessed a drastic rise in the advancement and incorporation of computerbased technology into several unit operations. Drug dissolution profiling is an important consideration for the successful development of immediate and… read more here.
Keywords: dissolution data; based pharmacokinetic; pbpk modelling; physiologically based ... See more keywords