Biorelevant and Screening Dissolution Methods for Minocycline Hydrochloride Microspheres Intended for Periodontal Administration.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120261
Abstract: Currently, there is no compendial-level method to assess dissolution of particulate systems administered in the periodontal pocket. This work seeks to develop dissolution methods for extended release poly(lactic-co-glycolic acid) (PLGA) microspheres applied in the periodontal… read more here.
Keywords: biorelevant; minocycline hydrochloride; dissolution methods; dissolution ... See more keywords
Towards Developing Discriminating Dissolution Methods for Formulations Containing Nano-Particulates in Solution; The Impact of Particle Drift and Drug Activity in Solution.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00599
Abstract: Enabling formulations are an attractive approach to increase the dissolution rate, solubility, and oral bioavailability of poorly soluble compounds. With the growing prevalence of poorly-soluble drug compounds in the pharmaceutical pipeline, supersaturating drug delivery systems… read more here.
Keywords: drug; dissolution methods; activity solution; drug activity ... See more keywords
Design and Evaluation of Two-Step Biorelevant Dissolution Methods for Docetaxel Oral Formulations
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02256-2
Abstract: Dissolution is a pivotal tool for oral formulations. Dissolution could be used to either reduce the risk of product failure through quality control or predict and understand in vivo performance of drug formulations. The latter… read more here.
Keywords: two step; biorelevant dissolution; dissolution; step biorelevant ... See more keywords