A novel microdialysis‐dissolution/permeation system for testing oral dosage forms: A proof‐of‐concept study
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DOI: 10.1016/j.ejps.2016.09.018
Abstract: &NA; A novel microdialysis‐dissolution/permeation (M‐D/P) system was developed for the biopharmaceutical assessment of oral drug formulations. This system consists of a side‐by‐side diffusion chamber, a microdialysis unit fixed within the dissolution chamber for continuous sampling,… read more here.
Keywords: novel microdialysis; dissolution; dissolution permeation; system ... See more keywords
Optimization of the Ussing chamber setup with excised rat intestinal segments for dissolution/permeation experiments of poorly soluble drugs
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DOI: 10.1080/03639045.2016.1251449
Abstract: Abstract Context: Prediction of the in vivo absorption of poorly soluble drugs may require simultaneous dissolution/permeation experiments. In vivo predictive media have been modified for permeation experiments with Caco-2 cells, but not for excised rat… read more here.
Keywords: permeation experiments; excised rat; permeation; intestinal segments ... See more keywords
In Vitro-In Vivo Predictive Dissolution-Permeation-Absorption Dynamics of Highly Permeable Drug Extended-Release Tablets via Drug Dissolution/Absorption Simulating System and pH Alteration
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DOI: 10.1208/s12249-018-0996-1
Abstract: Each of dissolution and permeation may be a rate-limiting factor in the absorption of oral drug delivery. But the current dissolution test rarely took into consideration of the permeation property. Drug dissolution/absorption simulating system (DDASS)… read more here.
Keywords: absorption; permeation; ddass; drug ... See more keywords