Rational Design of Rapidly Separating Dissolving Microneedles for Precise Drug Delivery by Balancing the Mechanical Performance and Disintegration Rate.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201900898
Abstract: The precise delivery of traditional dissolving microneedles (TDMNs) is often limited by the incomplete insertion due to the skin deformation, and the topical irritation is inevitable after long application, which ultimately results in compromised therapeutic… read more here.
Keywords: precise drug; rapidly separating; dissolving microneedles; drug delivery ... See more keywords
Collagen-based dissolving microneedles with flexible pedestals: A transdermal delivery system for both anti-aging and skin diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203295
Abstract: Biocompatible polymer microneedles (MNs) are emerging as a promising platform for transdermal drug delivery, especially for facial treatments. Therefore, the MN patch in this study used hydrolyzed collagen (HC) contained in skin cells as the… read more here.
Keywords: skin; dissolving microneedles; based dissolving; drug ... See more keywords
TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2020.11.013
Abstract: Abstract Nanoparticles (NPs) have shown potential in cancer therapy, while a single administration conferring a satisfactory outcome is still unavailable. To address this issue, the dissolving microneedles (DMNs) were developed to locally deliver functionalized NPs… read more here.
Keywords: tumor; dissolving microneedles; acid dual; hyaluronic acid ... See more keywords
Local dermal delivery of cyclosporin A, a hydrophobic and high molecular weight drug, using dissolving microneedles
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.02.014
Abstract: Graphical abstract Descriptive figure of a locally dermal delivery of cyclosporin A (CyA) using dissolving microneedles (a) after insertion into skin (b) stay of CyA for a longer time in skin after dissolution of polymer… read more here.
Keywords: dissolving microneedles; delivery; high molecular; molecular weight ... See more keywords
Hyaluronan‐based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.11.013
Abstract: Graphical abstract Figure. No caption available. Abstract The purpose of this study was to optimize the manufacturing of dissolving microneedles (dMNs) and to increase the antigen loading in dMNs to investigate the effect on their… read more here.
Keywords: dissolving microneedles; high antigen; antigen; intradermal vaccination ... See more keywords
Development and evaluation of new methods for protein quantification in dissolving microneedles formulations.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113453
Abstract: Dissolving microneedles (DMNs) are vital for the transdermal delivery of protein-based drugs due to their painless penetration, effective drug permeation, and safety characteristics. Thus, it is necessary to quantify the proteins encapsulated inside the DMNs.… read more here.
Keywords: quantification; dissolving microneedles; bca assay; protein quantification ... See more keywords
Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.07.027
Abstract: The purpose of this study was to investigate the feasibility of delivering sinomenine hydrochloride (SH) transdermally using composite dissolving microneedles (DM) which integrated with liquid crystals (H2). The fabricated SH-loaded composite DM was evaluated for… read more here.
Keywords: microneedles integrated; integrated liquid; dissolving microneedles; delivery ... See more keywords
Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-19463-2
Abstract: Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article,… read more here.
Keywords: melanoma; via dissolving; stat3 sirna; dissolving microneedles ... See more keywords
Enhanced skin drug delivery using dissolving microneedles: A potential approach for the management of skin disorders.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on drug delivery"
DOI: 10.1080/17425247.2023.2190095
Abstract: INTRODUCTION For decades, finding effective long-term or disease-modifying treatments for skin disorders has been a major focus of scientists. The conventional drug delivery systems showed poor efficacy with high doses and are associated with side… read more here.
Keywords: drug; skin disorders; dissolving microneedles; drug delivery ... See more keywords
Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030378
Abstract: Ketoprofen is an anti-inflammatory agent that may cause gastric irritation if administered orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue. However, ketoprofen has a low solubility; therefore, it is essential… read more here.
Keywords: ketoprofen; pva pvp; dissolving microneedles; nanosuspension grinding ... See more keywords
Enhanced Skin Permeation and Controlled Release of β-Sitosterol Using Cubosomes Encrusted with Dissolving Microneedles for the Management of Alopecia
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16040563
Abstract: The use of synthetic medication for treating alopecia is restricted because of systemic exposure and related negative effects. Beta-sitosterol (β-ST), a natural chemical, has lately been studied for its potential to promote hair development. The… read more here.
Keywords: skin permeation; permeation controlled; controlled release; enhanced skin ... See more keywords