Selective stimulation of colonic L cells improves metabolic outcomes in mice
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DOI: 10.1007/s00125-020-05149-w
Abstract: Aims/hypothesis Insulin-like peptide-5 (INSL5) is found only in distal colonic L cells, which co-express glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). GLP-1 is a well-known insulin secretagogue, and GLP-1 and PYY are anorexigenic, whereas INSL5… read more here.
Keywords: stimulation; food intake; distal colonic; selective stimulation ... See more keywords
Duhamel operation for children with distal colonic dysmotility
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DOI: 10.1007/s00383-017-4108-1
Abstract: PurposeTo report outcomes of children with constipation refractory to medical management and manometrically proven distal colonic dysmotility, managed with rectosigmoidectomy followed by Duhamel operation (Duhamel).MethodsChildren who underwent a Duhamel from 2009 onwards for intractable constipation… read more here.
Keywords: constipation; duhamel operation; colonic dysmotility; distal colonic ... See more keywords
Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men
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DOI: 10.1080/19490976.2021.2009297
Abstract: ABSTRACT Infusions of the short-chain fatty acid (SCFA) acetate in the distal colon improved metabolic parameters in men. Here, we hypothesized that combining rapidly and slowly fermentable fibers will enhance distal colonic acetate production and… read more here.
Keywords: metabolic health; prediabetic men; lean prediabetic; distal colonic ... See more keywords