Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel.
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DOI: 10.1016/j.kint.2017.10.023
Abstract: Kir4.1 in the distal convoluted tubule plays a key role in sensing plasma potassium and in modulating the thiazide-sensitive sodium-chloride cotransporter (NCC). Here we tested whether dietary potassium intake modulates Kir4.1 and whether this is… read more here.
Keywords: potassium; distal convoluted; kir4; potassium intake ... See more keywords
Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis.
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DOI: 10.1016/j.kint.2021.06.030
Abstract: Adverse effects of calcineurin inhibitors (CNI), such as hypertension, hyperkalemia, acidosis, hypomagnesemia and hypercalciuria, have been linked to dysfunction of the distal convoluted tubule (DCT). To test this, we generated a mouse model with an… read more here.
Keywords: acidosis; calcineurin; distal convoluted; cnb1 mice ... See more keywords
Kir4.1 deletion prevents salt-sensitive hypertension in early streptozotocin-induced diabetic mice via Na+–Cl− cotransporter in the distal convoluted tubule
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DOI: 10.1097/hjh.0000000000003419
Abstract: Objectives: Functional impairment of renal sodium handling and blood pressure (BP) homeostasis is an early characteristic manifestation of type 1 diabetes. However, the underlying mechanisms remain unclear. Methods: Metabolic cages, radio-telemetry, immunoblotting, and electrophysiology were… read more here.
Keywords: stz; hypertension; distal convoluted; activity ... See more keywords
WNK4 kinase: role of chloride sensing in the distal convoluted tubule
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DOI: 10.1097/mnh.0000000000000683
Abstract: Purpose of review This review focuses on recent efforts in identifying with-no-lysine kinase 4 (WNK4) as a physiological intracellular chloride sensor and exploring regulators of intracellular chloride concentration ([Cl-]i) in the distal convoluted tubule (DCT).… read more here.
Keywords: convoluted tubule; wnk4; distal convoluted; chloride ... See more keywords
High-resolution temporal transcriptomic profiling of the distal convoluted tubule identifies an early adaptive response to furosemide
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DOI: 10.1152/physiol.2023.38.s1.5734632
Abstract: The distal convoluted tubule (DCT) undergoes hypertrophy and hyperplasia to increase salt absorption in response to physiologic and pathological stresses, and has been implicated in the development of loop-diuretic resistance. However, the molecular mechanisms underlying… read more here.
Keywords: convoluted tubule; distal convoluted; high resolution; physiology ... See more keywords
HIV-1 Vpr suppresses expression of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule
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DOI: 10.1371/journal.pone.0273313
Abstract: HIV-associated nephropathy (HIVAN) impairs functions of both glomeruli and tubules. Attention has been previously focused on the HIVAN glomerulopathy. Tubular injury has drawn increased attention because sodium wasting is common in hospitalized HIV/AIDS patients. We… read more here.
Keywords: vpr transgenic; sodium; distal convoluted; transgenic mice ... See more keywords
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule
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DOI: 10.15252/emmm.202114273
Abstract: Epidemiological and clinical observations have shown that potassium ingestion is inversely correlated with arterial hypertension prevalence and cardiovascular mortality. The higher the dietary potassium, the lower the blood pressure and mortality. This phenomenon is explained,… read more here.
Keywords: distal convoluted; potassium; blood pressure; salt reabsorption ... See more keywords
Control of sodium and potassium homeostasis by renal distal convoluted tubules
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DOI: 10.1590/1414-431x2023e12392
Abstract: Distal convoluted tubules (DCT), which contain the Na-Cl cotransporter (NCC) inhibited by thiazide diuretics, undergo complex modulation to preserve Na+ and K+ homeostasis. The lysine kinases 1 and 4 (WNK1 and WNK4), identified as hyperactive… read more here.
Keywords: hypokalemia; distal convoluted; control sodium; homeostasis ... See more keywords