Role of paraoxonase 3 (PON3) in regulating ENaC-mediated sodium transport in distal nephron
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DOI: 10.1152/physiol.2023.38.s1.5731198
Abstract: PON3 is expressed in the aldosterone-sensitive distal nephron, where ENaC plays an essential role in maintaining Na+/K+ homeostasis in the kidney. The aims of our study were to determine the physiological roles of PON3 in… read more here.
Keywords: distal nephron; enac; role; physiology ... See more keywords
Defining corticosteroid-regulated sodium transport within the distal nephron
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DOI: 10.1152/physiol.2023.38.s1.5735058
Abstract: The aldosterone (ALDO)-sensitive distal nephron is typically defined as: the late distal convoluted tubule (DCT2), connecting tubule (CNT) and cortical collecting duct (CCD). ALDO-sensitivity is defined by 11βHSD2 (11β) activity (which inactivates corticosterone, CORT); mineralocorticoid… read more here.
Keywords: distal nephron; enac; cnt; physiology ... See more keywords
WNK4 limits distal calcium losses following acute furosemide treatment
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DOI: 10.14814/phy2.14195
Abstract: The distal nephron is essential for calcium homeostasis. This is evidenced by disordered calcium transport following disrupted distal nephron function occurring in salt‐wasting tubulopathies or with diuretic use. A plethora of studies support a role… read more here.
Keywords: distal nephron; wnk4; treatment; following acute ... See more keywords