Copper-Catalyzed, N-Directed Distal C(sp3)-H Functionalization toward Azepanes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03135
Abstract: We herein report a copper-catalyzed formal [5 + 2] aza-annulation of N-fluorosulfonamides and 1,3-dienes/1,3-enynes for synthesis of structurally diverse alkene/alkyne-containing azepanes. The reaction features selective functionalization of distal unactivated C(sp3)-H bonds and a broad substrate… read more here.
Keywords: distal sp3; catalyzed directed; directed distal; sp3 functionalization ... See more keywords
Diverse strategies for transition metal catalyzed distal C(sp3)–H functionalizations
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc04676k
Abstract: Transition metal catalyzed C(sp3)–H functionalization is a rapidly growing field. Despite severe challenges, distal C–H functionalizations of aliphatic molecules by overriding proximal positions have witnessed tremendous progress. While usage of stoichiometric directing groups played a… read more here.
Keywords: distal sp3; directing groups; transition metal; diverse strategies ... See more keywords