M2 polarization of macrophages by Oncostatin M in hypoxic tumor microenvironment is mediated by mTORC2 and promotes tumor growth and metastasis.
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DOI: 10.1016/j.cyto.2018.03.032
Abstract: Oncostatin M (OSM), an inflammatory cytokine belonging to the interleukin-6 (IL-6) superfamily, plays a vital role in multitude of physiological and pathological processes. Its role in breast tumor progression and metastasis to distant organs is… read more here.
Keywords: tumor; distant organs; polarization macrophages; polarization ... See more keywords