Construction of Distant Stereocenters by Enantioselective Desymmetrizing Carbonyl-Ene Reaction.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b01329
Abstract: An efficient desymmetrizing carbonyl-ene reaction of 1-substituted 4-methylenecyclohexanes with glyoxal derivatives was thus executed by a chiral N,N'-dioxide/NiII catalyst, providing facile access to cyclohexene derivatives bearing two remote 1,6-related stereocenters. This distal stereocontrol methodology originates… read more here.
Keywords: carbonyl ene; desymmetrizing carbonyl; distant stereocenters; ene reaction ... See more keywords
Stereoselective Preparation of Distant Stereocenters (1,5) within Acyclic Molecules
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c01762
Abstract: The development of a modular and diastereodivergent approach to acyclic products bearing two distant stere-ocenters in a 1,5 relationship is reported. Remarkably, it was accomplished in just three ... read more here.
Keywords: stereoselective preparation; acyclic molecules; preparation distant; within acyclic ... See more keywords