Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response
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DOI: 10.1007/s00018-021-03902-x
Abstract: The Cytolethal Distending Toxin (CDT) is a bacterial genotoxin produced by pathogenic bacteria causing major foodborne diseases worldwide. CDT activates the DNA Damage Response and modulates the host immune response, but the precise relationship between… read more here.
Keywords: response; distending toxin; cdt; exposure ... See more keywords
Horizontal transfer of bacterial cytolethal distending toxin B genes to insects.
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DOI: 10.1093/molbev/msz146
Abstract: Horizontal gene transfer (HGT) events have played a major role in the evolution of microbial species, but their importance in animals is less clear. Here we report HGT of cytolethal distending toxin B (cdtB), prokaryotic… read more here.
Keywords: insects; horizontal transfer; distending toxin; transfer bacterial ... See more keywords
Campylobacter jejuni Cytolethal Distending Toxin Induces GSDME-Dependent Pyroptosis in Colonic Epithelial Cells
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DOI: 10.3389/fcimb.2022.853204
Abstract: Background Cytolethal distending toxin (CDT) is a critical virulence factor of Campylobacter jejuni, and it induces cell death and regulates inflammation response in human epithelial cells. Pyroptosis is an inflammatory form of programmed cell death… read more here.
Keywords: campylobacter jejuni; pyroptosis; cdt; distending toxin ... See more keywords