Cochlear connexin 30 homomeric and heteromeric channels exhibit distinct assembly mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2018.10.001
Abstract: Many of the mutations in GJB2 and GJB6, which encode connexins 26 and 30 (Cx26 and Cx30), impair the formation of membrane channels and cause autosomal syndromic and non-syndromic hearing loss. In cochlear non-sensory supporting… read more here.
Keywords: homomeric heteromeric; distinct assembly; exhibit distinct; heteromeric gap ... See more keywords
A distinct assembly pathway of the human 39S late pre-mitoribosome
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24818-x
Abstract: Assembly of the mitoribosome is largely enigmatic and involves numerous assembly factors. Little is known about their function and the architectural transitions of the pre-ribosomal intermediates. Here, we solve cryo-EM structures of the human 39S… read more here.
Keywords: 39s late; distinct assembly; pre; assembly pathway ... See more keywords