Distinct biological ages of organs and systems identified from a multi-omics study.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110459
Abstract: Biological age (BA) has been proposed to evaluate the aging status instead of chronological age (CA). Our study shows evidence that there might be multiple "clocks" within the whole-body system: systemic aging drivers/clocks overlaid with… read more here.
Keywords: organs systems; multi omics; biological ages; distinct biological ... See more keywords
Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac037
Abstract: Tissue inhibitors of metalloproteinases (TIMPs) are a conserved family of proteins that were originally identified as endogenous inhibitors of matrixin and adamalysin endopeptidase activity. The matrixins and adamalysins are the major mediators of extracellular matrix… read more here.
Keywords: biological functions; unravelling distinct; distinct biological; functions potential ... See more keywords
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac224
Abstract: BACKGROUND Meningiomas, the most common primary intracranial tumors, can be separated into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and therapeutic vulnerabilities. Alternative meningioma grouping schemes using copy number variants, gene expression… read more here.
Keywords: methylation; dna methylation; distinct biological; hypermitotic meningiomas ... See more keywords
Infantile leukemia—What factors determine its distinct biological nature? Clinicopathological study of 78 cases
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13540
Abstract: Infantile leukemia encompasses a heterogeneous group which needs stratifying for treatment selection. read more here.
Keywords: infantile leukemia; factors determine; determine distinct; leukemia factors ... See more keywords