Two distinct conformers of SAG investigated by solution NMR and variable‐temperature experiments
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.12.019
Abstract: &NA; SAG (Smo agonist) is high specific agonist of Smo receptor, it is widely used as chemical probe to explore the therapeutic value of activating the Hh‐signaling pathway. In the present work, the coexistence of… read more here.
Keywords: solution nmr; distinct conformers; smo receptor; conformers sag ... See more keywords
Distinct Conformers of Assembled Tau in Alzheimer's and Pick's Diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor symposia on quantitative biology"
DOI: 10.1101/sqb.2018.83.037580
Abstract: Tau filaments with distinct morphologies and/or isoform compositions underlie a large number of human neurodegenerative diseases. In conjunction with experimental studies, this has led to the suggestion that conformers of aggregated tau exist. Electron cryo-microscopy… read more here.
Keywords: tau; amino acids; distinct conformers; conformers assembled ... See more keywords