Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica"
DOI: 10.1007/s00401-025-02857-8
Abstract: In Alzheimer’s disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progression, including Aβ plaque-associated microglia (PaM) and the newly identified coffin-like microglia (CoM). PaM are closely associated with amyloid-β (Aβ)… read more here.
Keywords: alzheimer disease; microglia aggregates; disease; define distinct ... See more keywords
Multiomics and Machine Learning Reveal Distinct Immune-Metabolic Signatures and Diagnostic Biomarkers for Asthma Inflammatory Endotypes
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c07657
Abstract: Background: bronchial asthma is a highly heterogeneous chronic inflammatory disease, with eosinophilic (EA) and neutrophilic (NEA) asthma subtypes exhibiting distinct pathological mechanisms and treatment responses. However, the protein-metabolite interactions underlying the pathogenesis of asthma remain… read more here.
Keywords: immune metabolic; distinct immune; machine learning; healthy controls ... See more keywords
Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00477-5
Abstract: Richter syndrome (RS) refers to transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma. RS is known to be associated with a number of genetic alterations such as… read more here.
Keywords: distinct immune; cll; lymphocytic leukemia; immune signatures ... See more keywords
Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "mAbs"
DOI: 10.1080/19420862.2020.1764829
Abstract: ABSTRACT Biologics have the potential to induce an immune response when used therapeutically. A number of in vitro assays are currently used preclinically to predict the risk of immunogenicity, but the validation of these preclinical… read more here.
Keywords: post hoc; distinct immune; immunogenicity; immune stimulatory ... See more keywords
Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06377-7
Abstract: Ionizing radiation can influence the antitumor immune response, either activating or suppressing the immune system depending on the tumor type and radiotherapy modality. While photon radiation (RT) combined with immunotherapy (IT) is widely studied in… read more here.
Keywords: responses proton; photon; combination; immune responses ... See more keywords
Distinct Immune Phenotypes in Infants Developing Asthma During Childhood
Sign Up to like & getrecommendations! Published in 2020 at "Pediatrics"
DOI: 10.1542/peds.2020-023861hhh
Abstract: AH Thysen, J Waage, JM Larsen. Sci Transl Med. 2020;12(529):eaaw0258 To address whether a deregulated immune response to generic microbial exposures in infancy is associated with later development of asthma. In this population-based birth cohort,… read more here.
Keywords: distinct immune; phenotypes infants; asthma childhood; immune phenotypes ... See more keywords
A single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1105673
Abstract: Introduction: Within the inflammatory immune response to viral infection, the distribution and cell type-specific profiles of immune cell populations and the immune-mediated viral clearance pathways vary according to the specific virus. Uncovering the immunological similarities… read more here.
Keywords: cell; immune responses; disease; distinct immune ... See more keywords
A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.926304
Abstract: Existing immune signatures and tumor mutational burden have only modest predictive capacity for the efficacy of immune check point inhibitors. In this study, we developed an immune-metabolic signature suitable for personalized ICI therapies. A classifier… read more here.
Keywords: signature; three distinct; distinct immune; immune metabolic ... See more keywords