Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome
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DOI: 10.1038/s41408-021-00477-5
Abstract: Richter syndrome (RS) refers to transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma. RS is known to be associated with a number of genetic alterations such as… read more here.
Keywords: distinct immune; cll; lymphocytic leukemia; immune signatures ... See more keywords
Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "mAbs"
DOI: 10.1080/19420862.2020.1764829
Abstract: ABSTRACT Biologics have the potential to induce an immune response when used therapeutically. A number of in vitro assays are currently used preclinically to predict the risk of immunogenicity, but the validation of these preclinical… read more here.
Keywords: post hoc; distinct immune; immunogenicity; immune stimulatory ... See more keywords
Distinct Immune Phenotypes in Infants Developing Asthma During Childhood
Sign Up to like & getrecommendations! Published in 2020 at "Pediatrics"
DOI: 10.1542/peds.2020-023861hhh
Abstract: AH Thysen, J Waage, JM Larsen. Sci Transl Med. 2020;12(529):eaaw0258 To address whether a deregulated immune response to generic microbial exposures in infancy is associated with later development of asthma. In this population-based birth cohort,… read more here.
Keywords: distinct immune; phenotypes infants; asthma childhood; immune phenotypes ... See more keywords
A single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1105673
Abstract: Introduction: Within the inflammatory immune response to viral infection, the distribution and cell type-specific profiles of immune cell populations and the immune-mediated viral clearance pathways vary according to the specific virus. Uncovering the immunological similarities… read more here.
Keywords: cell; immune responses; disease; distinct immune ... See more keywords
A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.926304
Abstract: Existing immune signatures and tumor mutational burden have only modest predictive capacity for the efficacy of immune check point inhibitors. In this study, we developed an immune-metabolic signature suitable for personalized ICI therapies. A classifier… read more here.
Keywords: signature; three distinct; distinct immune; immune metabolic ... See more keywords