SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208525120
Abstract: Significance Viruses may downregulate MHC class I expression on infected cells to avoid elimination by cytotoxic T cells. We report that the accessory proteins ORF7a and ORF3a of SARS-CoV-2 mediate this function and delineate the… read more here.
Keywords: expression; orf7a orf3a; distinct mechanisms; accessory proteins ... See more keywords
Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.1101/2021.10.27.466197
Abstract: The microtubule-associated proteins Map7D2 and Map7D1, which belong to the MAP7 family, stabilize microtubules through distinct mechanisms for the control of cell motility and neurite outgrowth. Microtubule (MT) dynamics are modulated through the coordinated action… read more here.
Keywords: stabilization; neurite outgrowth; map7d2 map7d1; microtubule ... See more keywords
Distinct mechanisms of dysfunctional antigen-presenting DCs and monocytes by single-cell sequencing in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer science"
DOI: 10.1111/cas.15800
Abstract: Multiple myeloma (MM) is an incurable plasma cell malignancy with the hallmark of immunodeficiency, including dysfunction of T cells, NK cells and antigen presentation cells (APC). Dysfunctional APCs have been reported to play a key… read more here.
Keywords: cell; distinct mechanisms; analysis; single cell ... See more keywords
Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02726-21
Abstract: The development of novel antibiotics is essential because the current arsenal of antimicrobials will soon be ineffective due to the widespread occurrence of antibiotic resistance. The development of naturally occurring cationic antimicrobial peptides (CAMPs) for… read more here.
Keywords: development; naturally occurring; resistance; antimicrobial peptides ... See more keywords
Transcriptome-wide analyses of piRNA binding sites suggest distinct mechanisms regulate piRNA binding and silencing in C. elegans.
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079441.122
Abstract: PIWI-interacting RNAs (piRNAs) protect genome integrity by silencing transposon mRNAs and some endogenous mRNAs in various animals. However, C. elegans piRNAs only trigger gene silencing at select predicted targeting sites, suggesting additional cellular mechanisms regulate… read more here.
Keywords: regulate pirna; transcriptome wide; mechanisms regulate; distinct mechanisms ... See more keywords
MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201744445
Abstract: MacroH2A histone variants suppress tumor progression and act as epigenetic barriers to induced pluripotency. How they impart their influence on chromatin plasticity is not well understood. Here, we analyze how the different domains of macroH2A… read more here.
Keywords: distinct mechanisms; histone variants; chromatin plasticity; two distinct ... See more keywords
An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01425
Abstract: Nuclear factor kappa B (NFκB) is a transcription factor that controls inflammation and cell survival. In clinical histology, elevated NFκB activity is a hallmark of poor prognosis in inflammatory disease and cancer, and may be… read more here.
Keywords: type interferons; distinct mechanisms; type; activity calculator ... See more keywords
Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.21481
Abstract: Optimal decision-making requires balancing fast but error-prone and more accurate but slower decisions through adjustments of decision thresholds. Here, we demonstrate two distinct correlates of such speed-accuracy adjustments by recording subthalamic nucleus (STN) activity and… read more here.
Keywords: decision; speed accuracy; distinct mechanisms; accuracy ... See more keywords