p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Biochimie"
DOI: 10.1016/j.biochi.2022.03.003
Abstract: Li-Fraumeni and Li-Fraumeni-like syndromes (LFS/LFL) are hereditary cancer predisposition disorders associated with germline mutations in the TP53 tumor suppressor gene. Here, we stably expressed LFS/LFL-associated p53 mutants R337H and G245S in p53-null H1299 cells to study… read more here.
Keywords: expression; p53 mutants; distinct metabolic; lfs lfl ... See more keywords
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Sign Up to like & getrecommendations! Published in 2021 at "Nature immunology"
DOI: 10.1038/s41590-020-00848-3
Abstract: Metabolic programming controls immune cell lineages and functions, but little is known about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ (IFN-γ) or interleukin-17 (IL-17) have intrinsically distinct… read more here.
Keywords: programs established; cell subsets; established thymus; distinct metabolic ... See more keywords
Fish Macrophages Show Distinct Metabolic Signatures Upon Polarization
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DOI: 10.3389/fimmu.2020.00152
Abstract: Macrophages play important roles in conditions ranging from host immune defense to tissue regeneration and polarize their functional phenotype accordingly. Next to differences in the use of L-arginine and the production of different cytokines, inflammatory… read more here.
Keywords: show distinct; metabolic reprogramming; distinct metabolic; metabolic signatures ... See more keywords
Distinct Metabolic States Are Observed in Hypoglycemia Induced in Mice by Ricin Toxin or by Fasting
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DOI: 10.3390/toxins14120815
Abstract: Hypoglycemia may be induced by a variety of physiologic and pathologic stimuli and can result in life-threatening consequences if untreated. However, hypoglycemia may also play a role in the purported health benefits of intermittent fasting… read more here.
Keywords: metabolic states; ricin; hypoglycemia; ricin toxin ... See more keywords