Distinct molecular mechanisms control levels of synaptic F‐actin
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11226
Abstract: Polymerization of filamentous (F)‐actin at the neuronal synapse plays an important role in neuronal function. However, the regulatory mechanisms controlling the levels of synaptic actin remain incompletely understood. Here, I used established pharmacological blockers to… read more here.
Keywords: actin; distinct molecular; synaptic actin; levels synaptic ... See more keywords
PSC subtyping based on TTF‐1 and p40 expression reveals distinct molecular characteristics and therapeutic strategies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34137
Abstract: Pulmonary sarcomatoid carcinoma (PSC) is a unique form of poorly differentiated nonsmall cell lung cancer (NSCLC) and is notorious for its highly malignant nature and dismal prognosis. To introduce effective treatment for PSC patients, precise… read more here.
Keywords: positive subgroup; distinct molecular; subgroup; three subgroups ... See more keywords
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.066
Abstract: SUMMARY Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several pathogenic mutations have been identified, the vast majority of ALS cases have no family history… read more here.
Keywords: cortex samples; distinct molecular; stress; postmortem cortex ... See more keywords
Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models
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DOI: 10.1038/s41467-018-03788-7
Abstract: Feingold syndrome is a skeletal dysplasia caused by loss-of-function mutations of either MYCN (type 1) or MIR17HG that encodes miR-17-92 microRNAs (type 2). Since miR-17-92 expression is transcriptionally regulated by MYC transcription factors, it has… read more here.
Keywords: feingold syndrome; distinct molecular; type; deficiency ... See more keywords
Risk of lung adenocarcinoma from smoking and radiation arises in distinct molecular pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz036
Abstract: KRAS mutations of lung adenocarcinoma (LADC) are associated with smoking but little is known on other exposure-oncogene associations. Hypothesizing that different inciting agents may cause different driver mutations, we aimed to identify distinct molecular pathways… read more here.
Keywords: lung adenocarcinoma; risk; exposure; distinct molecular ... See more keywords
Microautophagy – distinct molecular mechanisms handle cargoes of many sizes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.246322
Abstract: ABSTRACT Autophagy is fundamental for cell and organismal health. Two types of autophagy are conserved in eukaryotes: macroautophagy and microautophagy. During macroautophagy, autophagosomes deliver cytoplasmic constituents to endosomes or lysosomes, whereas during microautophagy lytic organelles… read more here.
Keywords: type microautophagy; distinct molecular; microautophagy distinct; microautophagy ... See more keywords
MR Imaging–Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma
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DOI: 10.3174/ajnr.a5899
Abstract: BACKGROUND AND PURPOSE: Distinct molecular subgroups of pediatric medulloblastoma confer important differences in prognosis and therapy. Currently, tissue sampling is the only method to obtain information for classification. Our goal was to develop and validate… read more here.
Keywords: distinct molecular; area; imaging based; based radiomic ... See more keywords
Distinct Molecular Mechanisms Characterizing Pathogenesis of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Microbiology and Biotechnology"
DOI: 10.4014/jmb.2206.06064
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has continued for over 2 years, following the outbreak of coronavirus-19 (COVID-19) in 2019. It has resulted in enormous casualties and severe economic crises. The rapid… read more here.
Keywords: vaccines therapeutics; distinct molecular; mechanisms characterizing; molecular mechanisms ... See more keywords
Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilities
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DOI: 10.7150/thno.63417
Abstract: Purpose: To establish a clinically applicable genomic clustering system, we investigated the interactive landscape of driver mutations in intrahepatic cholangiocarcinoma (ICC). Methods: The genomic data of 1481 ICCs from diverse populations was analyzed to investigate… read more here.
Keywords: distinct molecular; intrahepatic cholangiocarcinoma; mutations intrahepatic; mutation ... See more keywords