Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24205-6
Abstract: Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic integrity. However, the factors that control these different outcomes are often not well… read more here.
Keywords: pathways homologous; sws1 swsap1; swsap1 spidr; distinct pathways ... See more keywords
Prenatal Development and Adolescent Obesity: Two Distinct Pathways to Diabetes in Adulthood.
Sign Up to like & getrecommendations! Published in 2018 at "Childhood obesity"
DOI: 10.1089/chi.2017.0290
Abstract: OBJECTIVE Higher body-mass index (BMI) and lower birth weight (BW) are associated with elevated risk of diabetes in adulthood, but the extent to which they compose two distinct pathways is unclear. METHODS We used data… read more here.
Keywords: pre diabetes; diabetes adulthood; bmi; distinct pathways ... See more keywords
IRX4204 in combination with erlotinib to target distinct pathways in lung cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e14095
Abstract: e14095Background: IRX4204 is a Retinoid X Receptor (RXR) specific agonist (rexinoid). IRX4204 has high potency as a RXR agonist with low binding affinity to Retinoic Acid Receptors (RARs), PPAR, FX... read more here.
Keywords: pathways lung; irx4204 combination; distinct pathways; target distinct ... See more keywords
Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.76038
Abstract: Key protein adapters couple translation to mRNA decay on specific classes of problematic mRNAs in eukaryotes. Slow decoding on non-optimal codons leads to codon-optimality-mediated decay (COMD) and prolonged arrest at stall sites leads to no-go… read more here.
Keywords: distinct elongation; syh1 smy2; distinct pathways; degradation ... See more keywords