Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice
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DOI: 10.1038/s41598-019-42209-7
Abstract: Transverse aortic constriction (TAC) is a well-established model of pressure overload-induced cardiac hypertrophy and failure in mice. The degree of constriction “tightness” dictates the TAC severity and is determined by the gauge (G) of needle… read more here.
Keywords: distinct phenotypes; aortic constriction; tac; mice ... See more keywords
Chondrocytes from Osteoarthritis Patients Adopt Distinct Phenotypes in Response to Central TH1/TH2/TH17 Cytokines
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DOI: 10.3390/ijms22179463
Abstract: Chronic low-grade inflammation plays a central role in the pathogenesis of osteoarthritis (OA), and several pro- and anti-inflammatory cytokines have been implicated to mediate and regulate this process. Out of these cytokines, particularly IFNγ, IL-1β,… read more here.
Keywords: cells macrophages; patients adopt; distinct phenotypes; osteoarthritis patients ... See more keywords