Two functionally distinct subsets of IL‐17 producing γδ T cells
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DOI: 10.1111/imr.12905
Abstract: The γδ T cells play an important role in both mice and humans as a source of the cytokine IL‐17, which is key for immune resistance to certain pathogens. In mice, most of these IL‐17… read more here.
Keywords: distinct subsets; producing cells; subsets producing; functionally distinct ... See more keywords
Abstract A082: Distinct subsets of cytotoxic CD8 T cells delineate the rare pancreatic tumors that respond to PD-1 blockade
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DOI: 10.1158/1538-7445.pancreatic25-a082
Abstract: Inhibitors of the immune checkpoint PD-1 (ɑPD1) have had spectacular success in otherwise highly lethal malignancies, such as metastatic melanoma, but are ineffective in pancreatic ductal adenocarcinoma (PDAC), despite evidence of tumor infiltration by PD1+… read more here.
Keywords: cancer; distinct subsets; pd1; tumor ... See more keywords
Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation
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DOI: 10.3389/fimmu.2023.1139204
Abstract: Macrophage polarization is a process whereby macrophages develop a specific phenotype and functional response to different pathophysiological stimuli and tissue environments. In general, two main macrophage phenotypes have been identified: inflammatory (M1) and alternatively activated… read more here.
Keywords: nur77 ppar; transcription; regulate transcription; ppar regulate ... See more keywords