Absorption, Distribution, Metabolism, and Excretion of a New Herbicide, Epyrifenacil, in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c04167
Abstract: The metabolic fate of a newly developed herbicide, epyrifenacil, (ethyl[(3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetate, S-3100), in rats was determined using 14C-labeled epyrifenacil. When it was administered orally to rats at 1 mg/kg, around 73-74% of the dose was absorbed,… read more here.
Keywords: excretion; epyrifenacil; herbicide epyrifenacil; absorption distribution ... See more keywords
Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00160
Abstract: Absorption, distribution, metabolism, and excretion (ADME), which collectively define the concentration profile of a drug at the site of action, are of critical importance to the success of a drug candidate. Recent advances in machine… read more here.
Keywords: metabolism excretion; learning algorithms; distribution metabolism; machine learning ... See more keywords
Evaluation of in vitro absorption, distribution, metabolism, and excretion and assessment of drug-drug interaction of rucaparib, an orally potent poly(ADP-ribose) polymerase inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Xenobiotica"
DOI: 10.1080/00498254.2020.1737759
Abstract: Abstract 1. The absorption, distribution, metabolism, elimination, and drug-drug interaction (DDI) potential of the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib was characterised in vitro. 2. Rucaparib showed moderate cellular permeability, moderate human plasma protein binding (70.2%),… read more here.
Keywords: drug; rucaparib; absorption distribution; drug drug ... See more keywords
Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration–Approved Antisense Oligonucleotide Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000417
Abstract: Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes for determination of a drug’s pharmacokinetic parameters, which have direct impacts on efficacy and adverse drug reactions (ADRs). The chemical structures, dosage forms, and… read more here.
Keywords: distribution metabolism; drug; administration; aso drugs ... See more keywords
Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001006
Abstract: Human absorption, distribution, metabolism, and excretion (hADME) studies represent one of the most important clinical studies in terms of obtaining a comprehensive and quantitative overview of the total disposition of a drug. This article will… read more here.
Keywords: metabolism excretion; metabolism; distribution metabolism; absorption distribution ... See more keywords
A machine learning-based approach to ERα bioactivity and drug ADMET prediction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1087273
Abstract: By predicting ERα bioactivity and mining the potential relationship between Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) attributes in drug research and development, the development efficiency of specific drugs for breast cancer will be effectively improved… read more here.
Keywords: metabolism excretion; distribution metabolism; absorption distribution; prediction ... See more keywords
Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00034
Abstract: Aging is an inevitable biological process characterized by the loss of functional capacity and associated with changes in all phases of pharmacokinetic processes. Naringin, a dietary flavanone glycoside, has been proved to be beneficial for… read more here.
Keywords: aged rats; tissue distribution; pharmacokinetics tissue; naringin aged ... See more keywords
Distribution and metabolism of daidzein and its benzene sulfonates in vivo (in mice) based on MALDI-TOF MSI
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.918087
Abstract: Daidzein (D1) has been proved to be of great benefit to human health. More and more attention was paid to the metabolic process of D1. Most studies focused on the metabolites of D1 and analogs… read more here.
Keywords: distribution metabolism; tof msi; maldi tof; anti inflammatory ... See more keywords
Transporter-Mediated Subcellular Distribution in the Metabolism and Signaling of Jasmonates
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00390
Abstract: Jasmonates (jasmonic acid and its relatives) are a group of oxylipin phytohormones that are implicated in the regulation of a range of developmental processes and responses to environmental stimuli in plants. The biosynthesis of JAs… read more here.
Keywords: transporter mediated; mediated subcellular; subcellular distribution; distribution ... See more keywords
Homology Modeling, Docking, Absorption, Distribution, Metabolism, Excretion and Toxicity Studies and Prediction of Deleterious Non-Synonymous Single Nucleotide Polymorphisms (Nssnps) of Thiamin Phosphate Synthase: A Potential Drug Target in Plasmodium Falciparum
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Pharmaceutical Sciences"
DOI: 10.36468/pharmaceutical-sciences.692
Abstract: The drug resistance in malarial parasites is increasingly emerging, hence it is essential to discover and develop alternative anti-malarial agents against both new and established drug targets. One of such possible drug targets is thiamine… read more here.
Keywords: drug; absorption distribution; metabolism excretion; distribution metabolism ... See more keywords