MALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-0964-3
Abstract: AbstractGeneration of skin distribution profiles and reliable determination of drug molecule concentration in the target region are crucial during the development process of topical products for treatment of skin diseases like psoriasis and atopic dermatitis.… read more here.
Keywords: drug; development process; distribution profiles; skin distribution ... See more keywords
Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1099425
Abstract: Introduction: Niclosamide (Nc) is an FDA-approved anthelmintic drug that was recently identified in a drug repurposing screening to possess antiviral activity against SARS-CoV-2. However, due to the low solubility and permeability of Nc, its in… read more here.
Keywords: based pharmacokinetic; distribution profiles; tissue distribution; pharmacokinetic tissue ... See more keywords