A two-element high-lift airfoil in disturbed flow conditions
Sign Up to like & getrecommendations! Published in 2017 at "CEAS Aeronautical Journal"
DOI: 10.1007/s13272-016-0221-4
Abstract: This contribution presents experimental results of a two-element high-lift airfoil in a disturbed inflow. Permanent disturbances are generated by the wakes of two static airfoils located upstream of the research airfoil, one of which is… read more here.
Keywords: high lift; lift airfoil; two element; disturbed flow ... See more keywords
Single-cell RNA-seq analysis of mouse carotid artery under disturbed flow and human carotid plaques identifies key cell populations in atherosclerosis development
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-07395-7
Abstract: Atherosclerosis tends to occur in regions of disturbed blood flow. This study explored how disturbed flow aggravates atherosclerosis using single-cell RNA-seq (scRNA-seq) datasets from mouse carotid arteries under disturbed flow and human carotid artery plaques.… read more here.
Keywords: cell populations; carotid; single cell; analysis ... See more keywords
Disturbed flow disrupts the blood-brain barrier in a 3D bifurcation model.
Sign Up to like & getrecommendations! Published in 2019 at "Biofabrication"
DOI: 10.1088/1758-5090/ab5898
Abstract: The effect of disturbed flow profiles on the endothelium have been studied extensively in systemic vasculature, but less is known about the response of the blood-brain barrier (BBB) to these flow regimes. Here we investigate… read more here.
Keywords: brain barrier; disturbed flow; bifurcation; blood brain ... See more keywords
Vinculin phosphorylation impairs vascular endothelial junctions promoting atherosclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac647
Abstract: BACKGROUND AND AIMS Atherosclerosis preferentially develops in arterial branches and curvatures where vascular endothelium is exposed to disturbed flow. In this study, the effects of disturbed flow on the regulation of vascular endothelial phosphoproteins and… read more here.
Keywords: disturbed flow; vcls721p; atherosclerosis; promoting atherosclerosis ... See more keywords
Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/3491703
Abstract: Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. Ganoderma lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditions for more… read more here.
Keywords: medicine; stress inflammation; stress; disturbed flow ... See more keywords
Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial &bgr;1 Integrin
Sign Up to like & getrecommendations! Published in 2018 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.117.310491
Abstract: Objective— Accumulating evidence suggests a role of semaphorins in vascular homeostasis. Here, we investigate the role of Sema7A (semaphorin 7A) in atherosclerosis and its underlying mechanism. Approach and Results— Using genetically engineered Sema7A−/−ApoE−/− mice, we… read more here.
Keywords: sema7a; adhesion; bgr integrin; apoe mice ... See more keywords
Endothelial PHACTR1 Promotes Endothelial Activation and Atherosclerosis by Repressing PPARγ Activity Under Disturbed Flow in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.122.318173
Abstract: BACKGROUND Numerous genome-wide association studies revealed that SNPs at the PHACTR1 (phosphatase and actin regulator 1) locus strongly correlate with coronary artery disease. However, the biological function of PHACTR1 remains poorly understood. Here, we identified… read more here.
Keywords: phactr1; disturbed flow; atherosclerosis; mice ... See more keywords
Endothelial Yin Yang 1 Phosphorylation at S118 Induces Atherosclerosis Under Flow
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.121.319296
Abstract: Supplemental Digital Content is available in the text. Rationale: Disturbed flow occurring in arterial branches and curvatures induces vascular endothelial cell (EC) dysfunction and atherosclerosis. We postulated that disturbed flow plays important role in modulating… read more here.
Keywords: atherosclerosis; yin yang; phospho yy1s118; phosphorylation ... See more keywords
12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine"
DOI: 10.1186/s10020-025-01297-0
Abstract: Disturbed flow regions in the vasculature are predisposed to endothelial dysfunction and atherosclerotic plaque formation. The enzyme 12/15-lipoxygenase (12/15-LOX, encoded by ALOX15) has emerged as a promising therapeutic target for atherosclerosis. However, the relationship between… read more here.
Keywords: flow induced; atherosclerosis; endothelial dysfunction; disturbed flow ... See more keywords
Quercetin protects endothelial function from inflammation induced by localized disturbed flow by inhibiting NRP2 -VEGFC complex.
Sign Up to like & getrecommendations! Published in 2023 at "International immunopharmacology"
DOI: 10.2139/ssrn.4192445
Abstract: Atherosclerosis is a focal chronic inflammatory disease, the initial pathogenic event of which is endothelial dysfunction, and disturbed flow (DF) is the primary and vital factor underlying endothelial dysfunction. The present research aims to elucidate… read more here.
Keywords: inflammation; quercetin; disturbed flow; nrp2 vegfc ... See more keywords
Punicalagin Attenuates Disturbed Flow-Induced Vascular Dysfunction by Inhibiting Force-Specific Activation of Smad1/5
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.697539
Abstract: Background Pathophysiological vascular remodeling in response to disturbed flow with low and oscillatory shear stress (OSS) plays important roles in atherosclerosis progression. Pomegranate extraction (PE) was reported having anti-atherogenic effects. However, whether it can exert… read more here.
Keywords: dysfunction; flow induced; induced vascular; disturbed flow ... See more keywords