Nano Copper(0)-Stabilized on Alumina: Efficient and Recyclable Heterogeneous Catalyst for Chemoselective Synthesis of 1,2-Disubstituted Benzimidazoles and Quinoxalines in Aqueous Medium
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DOI: 10.1007/s10562-017-2166-6
Abstract: AbstractThe present communication elicits the use of copper nanoparticles on aluminium oxide derived from Cu–Al hydrotalcite as a heterogeneous catalyst in the green and operationally simple approach for the synthesis of selective 1,2-disubstituted benzimidazoles and… read more here.
Keywords: medium; copper; disubstituted benzimidazoles; catalyst ... See more keywords
Synthesis of 1,2-Fused/Disubstituted Benzimidazoles and Benzimidazolium Salts by I2-Mediated sp3 C-H Amination.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03630
Abstract: An intramolecular sp3 C-H amination reaction of aniline derivatives has been established. This reaction employs molecular iodine (I2) under transition-metal-free conditions and produces 1,2-fused or 1,2-disubstituted benzimidazoles. This operationally simple synthetic process works well with… read more here.
Keywords: disubstituted benzimidazoles; sp3 amination; fused disubstituted; benzimidazoles benzimidazolium ... See more keywords
Iridium(III)-Catalyzed One-Pot Access to 1,2-Disubstituted Benzimidazoles Starting from Imidamides and Sulfonyl Azides.
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DOI: 10.1021/acs.orglett.7b02028
Abstract: A novel Ir-catalyzed annulation of imidamides with sulfonyl azides has been developed. 1,2-Disubstituted benzimidazoles could be easily obtained in up to 99% yield for more than 40 examples. The products further streamline the synthesis of… read more here.
Keywords: iridium iii; iii catalyzed; imidamides sulfonyl; catalyzed one ... See more keywords
Mechanochemical Approach for the Selective Synthesis of 1,2-Disubstituted Benzimidazoles and Their Molecular Docking Studies
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DOI: 10.1080/10406638.2020.1768565
Abstract: A greener, scalable and mild mechanochemical protocol has been developed using readily available aromatic aldehydes and o-phenylenediamine in the presence of urea nitrate catalyst to afford 1,2-dis... read more here.
Keywords: selective synthesis; benzimidazoles molecular; mechanochemical approach; disubstituted benzimidazoles ... See more keywords
The Highly Efficient Synthesis of 1,2-Disubstituted Benzimidazoles Using Microwave Irradiation
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27051751
Abstract: The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clinically available benzimidazole-based… read more here.
Keywords: disubstituted benzimidazoles; synthesis disubstituted; synthesis; using microwave ... See more keywords