Stereoselective Palladium-Catalyzed 1,3-Arylboration of Unconjugated Dienes for Expedient Synthesis of 1,3-Disubstituted Cyclohexanes
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b02747
Abstract: As significant pharmacophores, 1,3-disubstituted cyclohexanes are widespread in natural products and synthetic bioactive molecules. In this work, we describe a palladium-catalyzed arylboration of 1,4-cyclohexadienes, which allows expeditious access to an array of functionalized 1,3-disubstituted cyclohexanes… read more here.
Keywords: synthesis; arylboration; catalyzed arylboration; disubstituted cyclohexanes ... See more keywords
Modular access to substituted cyclohexanes with kinetic stereocontrol
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abn9124
Abstract: Substituted six-membered cyclic hydrocarbons are common constituents of biologically active compounds. Although methods for the synthesis of thermodynamically favored, disubstituted cyclohexanes are well established, a reliable and modular protocol for the synthesis of their stereoisomers… read more here.
Keywords: access substituted; kinetic stereocontrol; disubstituted cyclohexanes; modular access ... See more keywords