Trialkylborane-Mediated Multicomponent Reaction for the Diastereoselective Synthesis of Anti-δ,δ-Disubstituted Homoallylic Alcohols.
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DOI: 10.1021/acs.orglett.8b03761
Abstract: The trialkylborane/O2-mediated reaction of propargyl acetates having a tributylstannyl group at an alkyne terminus with aldehydes in a THF-H2O solvent system gave anti-δ,δ-disubstituted homoallylic alcohols with good to high diastereoselectivity. Intriguingly, two alkyl groups derived… read more here.
Keywords: trialkylborane mediated; anti disubstituted; homoallylic alcohols; disubstituted homoallylic ... See more keywords
Iridium-Catalyzed Asymmetric Umpolung Allylation of N-Fluorenyl Imines to Prepare 1,4-Disubstituted Homoallylic Amines
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DOI: 10.1055/s-0036-1588514
Abstract: The discovery and development of an Ir-catalyzed asymmetric umpolung allylation of imines is discussed here. This method produces 1,4-disubstituted homoallylic amines, a class of compounds that are difficult to access by conventional methods. This reaction… read more here.
Keywords: catalyzed asymmetric; homoallylic amines; umpolung allylation; asymmetric umpolung ... See more keywords