Iridium-Catalyzed Asymmetric Hydrogenation of 4,6-Disubstituted 2-Hydroxypyrimidines.
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DOI: 10.1021/acs.orglett.8b02723
Abstract: An efficient iridium-catalyzed hydrogenation of 4,6-disubstituted 2-hydroxypyrimidines has been achieved, giving chiral cyclic ureas with excellent diastereoselectivities and up to 96% ee of enantioselectivities. In the presence of the in situ generated hydrogen halide, the… read more here.
Keywords: catalyzed asymmetric; hydrogenation; asymmetric hydrogenation; iridium catalyzed ... See more keywords