Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
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DOI: 10.1021/acs.jmedchem.0c01411
Abstract: A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During… read more here.
Keywords: disubstituted imidazopyridines; nsg mouse; plasmodium falciparum; vivo efficacy ... See more keywords