Catalyst-Controlled Divergent Reactions of 2,3-Disubstituted Indoles with Propargylic Alcohols: Synthesis of 3H-Benzo[b]azepines and Axially Chiral Tetrasubstituted Allenes.
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DOI: 10.1021/acs.orglett.2c02642
Abstract: Catalyst-controlled divergent reactions of 2,3-disubstituted indoles with propargylic alcohols were developed for the first time. In the presence of TsOH or B(C6F5)3 as catalyst, 2,3-disubstituted indoles reacted smoothly with 3-alkynyl-3-hydroxyisoindolinones to afford 3H-benzo[b]azepines by selective… read more here.
Keywords: controlled divergent; catalyst; disubstituted indoles; catalyst controlled ... See more keywords
Platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles with allylic acetates in water
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DOI: 10.1039/c8nj05051a
Abstract: Herein, we have demonstrated that the platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles proceeds in water. read more here.
Keywords: allylation disubstituted; selective allylation; disubstituted indoles; platinum catalyzed ... See more keywords
Synthesis of 2,3-disubstituted indoles via a tandem reaction
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DOI: 10.1039/d0qo00765j
Abstract: A strategy for the synthesis of 2,3-disubstituted indoles from 2-allyl-2-(2-nitrophenyl)cyclohexane-1,3-dione has been developed. A wide array of 2,3-disubstituted indoles were accessed in modest to good yields via a tandem reduction/condensation/fragmentation/cyclization sequence. The utility of this… read more here.
Keywords: via tandem; tandem reaction; indoles via; synthesis disubstituted ... See more keywords
Brønsted acid catalyzed remote C6 functionalization of 2,3-disubstituted indoles with β,γ-unsaturated α-ketoester
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DOI: 10.3389/fchem.2022.992398
Abstract: Graphical Abstract A metal-free catalytic approach for the remote C6-functionalization of 2,3-disubstituted indoles has been developed. In the presence of catalytic amounts of Brønsted acid, the β,γ-unsaturated α-ketoesters react with 2,3-disubstituted indoles at the C6… read more here.
Keywords: remote functionalization; functionalization disubstituted; disubstituted indoles; nsted acid ... See more keywords