Catalytic Asymmetric Cyclizative Rearrangement of Anilines and Vicinal Diketones to Access 2,2‐Disubstituted Indolin‐3‐ones
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DOI: 10.1002/advs.202402532
Abstract: The efficient synthesis of chiral 2,2‐disubstituted indolin‐3‐ones is of great importance due to its significant synthetic and biological applications. However, catalytic enantioselective methods for de novo synthesis of such heterocycles remain scarce. Herein, a novel… read more here.
Keywords: vicinal diketones; anilines vicinal; cyclizative rearrangement; disubstituted indolin ... See more keywords
Regioselective Cross-Coupling of Isatogens with Boronic Acids to Construct 2,2-Disubstituted Indolin-3-one Derivatives.
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DOI: 10.1021/acs.orglett.1c02808
Abstract: Herein we present a transition-metal-free cross-coupling reaction of isatogens with boronic acids through a 1,4-metalate shift of a boron "ate" complex. This coupling reaction provides a feasible method to deliver valuable 2,2-disubstituted indolin-3-one derivatives with… read more here.
Keywords: boronic acids; one derivatives; disubstituted indolin; indolin one ... See more keywords
Direct Oxidative Dearomatization of Indoles with Aromatic Ketones: Rapid Access to 2,2-Disubstituted Indolin-3-ones
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DOI: 10.1055/s-0039-1691528
Abstract: A metal-free oxidative dearomatization of indoles with aromatic ketones mediated by TEMPO oxoammonium salt is described. The dearomatization proceeds smoothly and displays a broad substrate scope with respect to both indoles and aromatic ketones in… read more here.
Keywords: aromatic ketones; oxidative dearomatization; disubstituted indolin; indoles aromatic ... See more keywords